Protein-protein interactions play key roles in leukocyte extravasation process into the brain and have been attractive therapeutic targets for inhibiting brain...
The FASEB Journal, Wiley, mars 2022, Volume : 36, Numéro : 3
The blood-brain barrier (BBB) prevents the majority of drugs from crossing into the brain and reaching neurons. To overcome this challenge, safe and...
Expert Opinion on Drug Discovery, Taylor & Francis, 12 mai 2020
Introduction: In vivo imaging technologies have become integral and essential component of drug discovery, development, and clinical assessment for central...
The Journal of Biochemistry, Oxford Academic, 8 novembre 2022, Volume : 173, Numéro : 2
Pathologies of the central nervous system impact a significant portion of our population, and the delivery of therapeutics for effective treatment is...
Antibody, immuno- and gene therapies developed for neurological indications face a delivery challenge posed by various anatomical and physiological barriers...
Journal of Cerebral Blood Flow & Metabolism, 7 mars 2012, Volume : 32, Numéro : 7
Pathophysiology of the neurovascular unit (NVU) is commonly seen in neurological diseases. The typical features of NVU pathophysiology include tissue hypoxia,...
Fluids and Barriers of the CNS, BMC, 26 mai 2023, Volume : 20, Numéro : 1
Blood brain barrier (BBB) models in vitro are an important tool to aid in the pre-clinical evaluation and selection of BBB-crossing therapeutics. Stem cell...
Journal of Cerebral Blood Flow & Metabolism, 23 juin 2016
Cerebrovascular insufficiency appears years prior to clinical symptoms in Alzheimer’s disease. The soluble, highly toxic amyloid-β species, generated from the...
Article de périodique (revue)
Filtrer vos résultats
Opération réussie
L’élément a été sauvegardé.
Opération réussie
Cet élément a été retiré.
Erreur
Vous avez dépassé le nombre maximal de 100 résultats sauvegardés.
Erreur
Impossible de sauvegarder l’élément. Veuillez réessayer. Si le problème persiste, il pourrait y avoir un problème avec l’élément.
Erreur
Impossible de supprimer l’article demandé. Veuillez réessayer plus tard.