Protein-protein interactions play key roles in leukocyte extravasation process into the brain and have been attractive therapeutic targets for inhibiting brain...
We have recently demonstrated the brain-delivery of an Amyloid-ß oligomer (Aßo)-binding peptide-therapeutic fused to the BBB-crossing single domain antibody...
The FASEB Journal, Wiley, mars 2022, Volume : 36, Numéro : 3
The blood-brain barrier (BBB) prevents the majority of drugs from crossing into the brain and reaching neurons. To overcome this challenge, safe and...
Antibody-based therapeutics have emerged as novel class of biopharmaceuticals over the last couple of decades with the advancements made in production and...
Fluids and Barriers of the CNS, BMC, 26 mai 2023, Volume : 20, Numéro : 1
Blood brain barrier (BBB) models in vitro are an important tool to aid in the pre-clinical evaluation and selection of BBB-crossing therapeutics. Stem cell...
Journal of Cerebral Blood Flow & Metabolism, Sage, mai 2022, Volume : 42, Numéro : 5
In vivo biomarker abnormalities provide measures to monitor therapeutic interventions targeting amyloid-β pathology as well as its effects on downstream...
The FASEB Journal, Federation of American Society of Experimental Biology, 2 avril 2020, Volume : 34, Numéro : 6
Prolonged serum half-life is required for the efficacy of most protein therapeutics. One strategy for half-life extension is to exploit the long circulating...
Journal of Cerebral Blood Flow & Metabolism, 23 juin 2016
Cerebrovascular insufficiency appears years prior to clinical symptoms in Alzheimer’s disease. The soluble, highly toxic amyloid-β species, generated from the...
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